Spectroscopic characterization of the compound and ASED-MO calculation of the trityl cation are reported. 同时还研究了该化合物的谱学性质,并用ASE&MO方法计算了它的电子结构。
The influences of reactant ratio, reaction temperature, reaction time on substitution reaction were studied. The better reaction conditions were obtained: molar ratio of trityl chloride and cuprous cyanide was 1:1.3, reaction temperature was at 130 ℃, reaction time was 2.5h. 并通过对原料配比、反应温度和反应时间的研究,得到了较佳的合成工艺条件:三苯基氯甲烷与氰化亚铜的最佳摩尔比为1:1.3,反应温度为130℃,反应时间为2.5小时。
An attempt to remove the trityl group of compound 3 under acidic conditions gave the new compound 4. The structures of the compounds 3 and 4 were confirmed by elementary analyses and spectroscopic methods. 化合物3在酸性条件下脱保护,制得化合物4。用元素分析和波谱方法确定化合物3和4的结构,用杯盘培养法测化合物4的抑菌活性。
Methods 3-one-12-hydroxy-13,14-ene-andrographolide was synthesized in a three-step route, including protecting primary alcohol of andrographolide by trityl ether, oxidating secondary alcohol and removing protecting group, etc. 方法通过三苯甲醚保护伯醇、氧化仲醇、脱去保护基的方法,合成3酮基12羟基13,14烯穿心莲内酯。
One-step Transformation of the Trityl Ether to the Acetonide 三苯甲基醚直接转化成丙酮化合物的反应